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Production

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Leading Contract Manufacturing Organization

As one of the leading pharmaceutical Contract manufacturing manufacturers in Belgium, we focus exclusively on the production of semi-solid products. Pannoc has built up decades of experience and in-depth technical expertise as a recognized market leader in the production of ointment bases for magisterial preparations. We use this expertise in the development and production of semi-solid formulas.

No tablets, no liquids. We are all about semi-solid products.

We maintain a strict quality assurance at every stage of the production process and use advanced equipment and methods that comply with international regulatory standards, including those of the EMA and GMP.

Once the dossier for your pharmaceutical product, medical device or health product has been approved, we are ready to produce for you. We take care of every phase of the production process on your behalf, minimizing lead times and allowing rapid market introduction.

At Pannoc, your creams, gels, lotions and other semi-solid products are in the hands of an expert.

Hand met een witte crème of lotion die op de palm wordt aangebracht.
At Pannoc, your creams, gels, lotions and other semi-solid products are in the hands of an expert.

Production process

Kremige substantie stroomt uit een metalen slang in een industriële tank.
1

Formula & Preparation

Preparation of the formula and weighing of ingredients.
Mixing, dissolving, homogenizing and processing into the end product.
2

Fill

Fill the product in the correct primary packaging and batch coding.
Quality control during and after the filling process
Verpakkingsmachine die een witte doos vaseline met blauwe tekst en druppelicoon op een lopende band verwerkt.
3

Packing

Secondary and tertiary packaging
Labelling, batch coding and product finalization.
Quality control during the packaging process.
Laboratoriumhanden met blauwe handschoenen die een petrischaal behandelen met een pipet, omgeven door meerdere petrischalen en flessen met vloeistoffen.
4

Release

Internal QC analysis
Quality assessment by QP, RP or QA

Preparation

We offer flexible batch sizes, from small-scale clinical production to full commercial production. This way, we can meet a variety of project requirements. Our facility is fully compliant with Good Manufacturing Practice (GMP) standards. This allows us to meet the highest quality requirements.

GMP certified
Cleanroom class D
Semi-solid products: creams, pastes, ointments, gels
Non-sterile medicines, cosmetics and medical devices
Flexible batch sizes:
From batch size 50 to 1,000 kg
Test batches
Our production vessels:
Temperature-controlled production, including cold and heat-treated processes
All production tanks are fully equipped with precise temperature control from 2 °C to 95 °C with homogenisation function
Advanced magnetic emulsion technology
Verpakkingsmachine die een witte doos vaseline met blauwe tekst en druppelicoon op een lopende band verwerkt.

Filling & packaging

We offer a wide range of packaging solutions designed to meet both regulatory and commercial objectives. This includes primary packaging that protects product integrity and secondary packaging that increases product visibility and appeal.

Labelling

One-sided/two-sided labeling (round packages)
Manual labelling when required by label design

Packaging of manufactured bulk products:

Tubes: 5 ml — 150 ml in plastic, laminate or aluminum
Jars: 20 ml — 5000 ml in PE, PET,...
Bottles: 20 ml — 5000 ml in PE, PET,...
Barrels: 10 kg — 200 kg...

For medical devices

Unique coding fully compliant with UDI (Unique Device Identification) as defined in the Medical Device Regulation (EU) 2017/745 (MDR).

Sterile production

Sterile production can be offered via autoclave/irradiation of the final product.
We are always open to discus and implement new packaging needs.
Twee lege witte cosmetische verpakkingen op een lichtgrijze achtergrond, een tube en een pompflacon.

Batch release

The release of finished products is carried out under strict regulations and quality standards to ensure patient safety and product integrity.

Drugs are released by a Qualified Person (QP), raw materials/compounding creams by the Responsible Pharmacist (RP), and other products supervised by our department Quality Assurance (QA). All release decisions are made by independent staff who are not involved in production, ensuring objectivity and regulatory compliance.

Prior to release, batch documents are thoroughly reviewed, all in-process controls are verified, and internal QC analyses are accurately performed in our laboratory. Each step of the process is documented and reviewed to ensure full compliance with applicable regulations and internal quality standards.

Kremige substantie stroomt uit een metalen slang in een industriële tank.

Quality Control — Fully Equipped Lab

Pannoc has its own in-house laboratory, specialized in the development and release of medicines, medical devices and health products. Because all phases are carried out internally, including microbiological tests, Pannoc maintains full control over the processes and guarantees a faster and more efficient product release.

Pannoc's fully equipped internal laboratory offers comprehensive quality controls to ensure the safety, efficacy and consistency of all products. These include:

Compliance testing of raw materials, packaging components, semi-finished products and finished products
In-process control to monitor critical parameters during production
Microbiological tests
Qualitative and quantitative determination of active substances, preservatives and other formulation components using techniques such as HPLC and TLC
Measurement of viscosity and pH
Spectrophotometric analysis
Water content determination with the Karl Fischer method
Determination of melting points and boiling points
Drop point analysis
Stability tests
Additional specialized analyses if required

Quality Assurance — At every step, for every product

Our Quality Assurance team ensures that all products and processes meet the highest regulatory and quality standards.

Compliance Management: We monitor compliance with international guidelines such as GMP, GLP and ICH, and continuously adapt procedures throughout the product lifecycle.
Verification of production and quality controls: We ensure that production processes and quality controls are carried out correctly, so that all products meet strict specifications and safety requirements.

We are fully committed to providing products that are 100% safe and consistently of the highest quality. Only the highest quality is good enough for Pannoc.

Only the highest quality is good enough for Pannoc.
Zwarte bolvormige bediening en een verlichte oranje knop op een witte wand gemonteerd.

Our facilities

Twee mensen in witte laboratoriumjassen en haarnetjes lopen in een schone gang met blauwe deuren en een automatische blauwe roldeur.

With experience since 1978, we have fully mastered the art of pharmaceutical production. Our ultra-modern production facility in Olen operates under a valid EU-GMP permit.

Een persoon wijst naar een computerscherm met Siemens SIMATIC HMI interface voor procesbesturing.

In 2019, we completely renewed the facility, creating a modern, state-of-the-art production environment. At the same time, we invested in a new water treatment system so that our productions are always provided with aqua purificata.

Zwarte bolvormige bediening en een verlichte oranje knop op een witte wand gemonteerd.

We are proud of our advanced cleanroom, which is designed with multiple zones according to a logical production flow and meets all regulatory requirements.

Proud of our state of the art cleanroom.
Gang met blauwe deuropeningen en een automatische snelroldeur in een schone, goed verlichte industriële of laboratoriumomgeving.

Pannoc as your Contract Manufacturer?

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Our licenses

EU-GMP Manufacturing
Manufacturing License for ointment bases used in pharmaceutical compounding

Our site is regularly inspected by the Belgian authorities (Federal Agency for Medicines and Health Products — FAMHP), as well as by our customers.